It could harm the unborn baby or cause birth defects. You may need to have a negative pregnancy test before starting this treatment.ĭo not use denosumab if you are pregnant. Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. This medicine may cause jaw bone problems ( osteonecrosis). If you are taking medicine that lower your blood calcium levels. If you cannot take daily calcium and vitamin D or If you are scheduled for a dental procedure Hypoparathyroidism (decreased functioning of the parathyroid glands) Īny condition that makes it hard for your body to absorb nutrients from food (malabsorption) Kidney disease (or if you are on dialysis) Ī weak immune system (caused by disease or by using certain medicines) While you are using Prolia, you should not receive Xgeva, another brand of denosumab. Low levels of calcium in your blood ( hypocalcemia) or You should not receive Prolia if you are allergic to denosumab, or if you have: You may need to stop using the medicine for a short time. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using Prolia. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Symptoms may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. Some people using Prolia have developed bone loss in the jaw, also called osteonecrosis of the jaw. Tell your doctor if you become pregnant.īefore you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. Use effective birth control while using this medicine and for at least 5 months after your last dose.
#Proelia definition skin#
Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems.ĭo not use denosumab if you are pregnant. Prolia can cause many serious side effects. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. Who cannot use another osteoporosis medicine or these medicines did not work well. Prolia is used in adults to treat osteoporosis or bone loss in people who: Xgeva is another brand of denosumab used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. This medication guide provides information about the Prolia brand of denosumab. This may help to protect healthy cells from damage. Monoclonal antibodies are made to target and destroy only certain cells in the body. Generic name: denosumab (Prolia) ĭrug class: Miscellaneous bone resorption inhibitors
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